Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
V Janssens, J Goris - Biochemical Journal, 2001 - portlandpress.com
Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …
minimally containing a well conserved catalytic subunit, the activity of which is highly …
Human telomerase and its regulation
YS Cong, WE Wright, JW Shay - Microbiology and molecular …, 2002 - Am Soc Microbiol
The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
Telomerase is a multicomponent reverse transcriptase enzyme that adds DNA repeats to the
ends of chromosomes using its RNA component as a template for synthesis. Telomerase …
ends of chromosomes using its RNA component as a template for synthesis. Telomerase …
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
SS Kang, T Kwon, SI Do - Journal of Biological Chemistry, 1999 - ASBMB
With the amino acid sequences of all reported Akt kinase physiological substrates, the
possible Akt kinase substrate specificity has been suggested. The serine/threonine residue …
possible Akt kinase substrate specificity has been suggested. The serine/threonine residue …
Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss
Desiccation of plants during drought can be detrimental to agricultural production. The
phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in …
phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in …
Protein phosphatases in plants
S Luan - Annual review of plant biology, 2003 - annualreviews.org
Phosphorylation and dephosphorylation of a protein often serve as an “on-and-off” switch in
the regulation of cellular activities. Recent studies demonstrate the involvement of protein …
the regulation of cellular activities. Recent studies demonstrate the involvement of protein …
Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer
The PPP2R1B gene, which encodes the β isoform of the A subunit of the serine/threonine
protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene …
protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene …
Natural and pharmacological regulation of telomerase
The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …
Dynamics of telomerase activity in response to acute psychological stress
Telomerase activity plays an essential role in cell survival, by lengthening telomeres and
promoting cell growth and longevity. It is now possible to quantify the low levels of …
promoting cell growth and longevity. It is now possible to quantify the low levels of …
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
RA Greenberg, RC Allsopp, L Chin, GB Morin… - Oncogene, 1998 - nature.com
We have identified the mouse telomerase reverse transcriptase component (mTERT) and
demonstrate both substantial sequence homology to the human ortholog (hTERT), and the …
demonstrate both substantial sequence homology to the human ortholog (hTERT), and the …