Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

Telomeres are specialized nucleoproteic complexes localized at the physical ends of linear
eukaryotic chromosomes that maintain their stability and integrity. The DNA component of …

Cells subjected to sub-lethal doses of stress such as irradiation or oxidative damage enter a
state that closely resembles replicative senescence. What triggers stress-induced premature …

In yeast, broken chromosomes can be repaired by recombination, resulting in nonreciprocal
translocations. In haploid cells suffering an HO endonuclease-induced, double-strand break …

Telomere maintenance is regarded as a key mechanism in overcoming cellular senescence
in tumor cells and in most cases is achieved by the activation of telomerase. However there …

Shortly after the discovery of polonium and radium by Marie Curie and her husband and
colleague, Pierre Curie, it was learned that exposure to these α-particle emitters produced …

Telomere has a central role in chromosomal stability events. Chromosome ends organized
in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus …

A fundamental characteristic of eukaryotic organisms is the generation of genetic variation
via sexual reproduction. Conversely, significant large-scale genome structure variations …

Anguimorphan lizards are a morphologically variable group of squamate reptiles with a wide
geographical distribution. In spite of their importance, they have been cytogenetically …

Double-strand breaks are a cataclysmic threat to genome integrity. In higher eukaryotes the
predominant recourse is the nonhomologous end-joining (NHEJ) double-strand break repair …