Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

During the past 2 decades, intracytoplasmic sperm injection (ICSI) has become a routine
technique for clinical applications in humans. The widespread use among domestic species …

ACE910 is a humanized anti-factor IXa/X bispecific antibody mimicking the function of factor
VIII (FVIII). We previously demonstrated in nonhuman primates that a single IV dose of …

Intracytoplasmic sperm injection (ICSI) has become a useful technique for clinical
applications in the horse-breeding industry. However, both ICSI blastocyst and offspring …

Hemophilia A (HA) and hemophilia B (HB) are X-linked bleeding disorders due to
inheritable deficiencies in either coagulation factor VIII (FVIII) or factor IX (FIX), respectively …

Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …

The X-linked bleeding disorder hemophilia is caused by mutations in coagulation factor VIII
(hemophilia A) or factor IX (hemophilia B). Unless prophylactic treatment is provided …

Animals that accurately model human disease are invaluable in medical research, allowing
a critical understanding of disease mechanisms, and the opportunity to evaluate the effect of …

Proof‐of‐principle disease models have demonstrated the feasibility of an intrauterine gene
modification therapy (in utero gene therapy (IUGT)) approach to hereditary diseases as …

Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-
million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII …