Pharmacological properties, therapeutic potential and molecular mechanisms of JWH133, a CB2 receptor-selective agonist

HM Hashiesh, C Sharma, SN Goyal, NK Jha… - Frontiers in …, 2021 - frontiersin.org
The endocannabinoid system has attracted attention as a pharmacological target for several
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …

Endocannabinoids as guardians of metastasis

I Tegeder - International Journal of Molecular Sciences, 2016 - mdpi.com
Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in
cancer pathophysiology in several ways, including tumor growth and progression …

The endocannabinoid anandamide attenuates acute respiratory distress syndrome by downregulating miRNA that target inflammatory pathways

M Sultan, H Alghetaa, A Mohammed… - Frontiers in …, 2021 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is defined as a type of respiratory failure that is
caused by a variety of insults such as pneumonia, sepsis, trauma and certain viral infections …

Role of Epigenome and Microbiome in Endocannabinoid-Mediated Regulation of Inflammation During Diet-Induced Obesity

K Miranda - 2019 - search.proquest.com
Obesity is an inflammatory disease involving accumulation of adipose tissue, gut microbiota
dysbiosis, and over-activation of the endocannabinoid system (ECS). Mechanisms involved …

Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain

E Nent - 2018 - bonndoc.ulb.uni-bonn.de
When normal nociceptive pain becomes chronic, it loses its protective function and causes a
general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused …

[PDF][PDF] Stress-induced exacerbation of LPS/GalN liver injury

M Killilea - 2018 - aran.library.nuigalway.ie
Stress is a key regulator of homeostasis in the body. However, aberrant activation of the
stress response has been implicated in predisposing to, and exacerbating processes that …