All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene
therapy owing to its minimal pathogenicity and ability to establish long-term gene expression …

Gene therapy is poised to revolutionize modern medicine, with seemingly unlimited potential
for treating and curing genetic disorders. For otherwise incurable indications, including most …

Background Hereditary angioedema is a rare genetic disease characterized by severe and
unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based …

Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and
increases with age. The proliferation of polyploid hepatocytes in vivo is restricted by the …

Abstract Background & Aims Gene therapy using recombinant adeno-associated virus
(rAAV) vector carrying multidrug resistance protein 3 (MDR3) coding sequence (AAV8 …

The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence
hepatocyte identity and function. Among the most well-studied mammalian polyploid cells …

The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …

Introduction Hepatotoxicity induced by immunotherapeutics is an appearing cause for
immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to …

Binucleated polyploid cells are common in many animal tissues, where they arise by
endomitosis, a non-canonical cell cycle in which cells enter M phase but do not undergo …