Bone self-healing is limited and generally requires external intervention to augment bone
repair and regeneration. While traditional methods for repairing bone defects such as …

Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …

Critical-sized bone defects are defined as those that will not heal spontaneously within a
patient's lifetime. Current treatment options include vascularized bone grafts, distraction …

Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …

Drug delivery systems composed of osteogenic substances and biological materials are of
great significance in enhancing bone regeneration, and appropriate biological carriers are …

In biomaterials science, it is nowadays well accepted that improving the biointegration of
dental and orthopedic implants with surrounding tissues is a major goal. However, implant …

Novel tissue regeneration strategies are constantly being developed worldwide. Research
on bone regeneration is noteworthy, as many promising new approaches have been …

Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of
materials for cell delivery is the lack of understanding of material properties that govern …

Injectable scaffolds are appealing for tissue regeneration because they offer many
advantages over pre-formed scaffolds. This article provides a comprehensive review of the …

Growth factors are very promising molecules to enhance bone regeneration. However, their
translation to clinical use has been seriously limited, facing issues related to safety and cost …