The CXCL12/CXCR4/ACKR3 axis in the tumor microenvironment: signaling, crosstalk, and therapeutic targeting
Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …
Atypical chemokine receptors in tumor cell growth and metastasis
BL Lokeshwar, G Kallifatidis, JJ Hoy - Advances in Cancer Research, 2020 - Elsevier
Atypical chemokine receptors (ACKRs) are seven-transmembrane cell surface protein
receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells …
receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells …
[HTML][HTML] D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling
Background Emphysematous COPD is characterized by aberrant alveolar repair.
Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its …
Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its …
EGFR‐rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway …
F Li, X Zhao, R Sun, J Ou, J Huang… - Journal of …, 2020 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is the most common cancer with high metastatic potential
that occurs in the epithelial cells of the nasopharynx. Distant metastases are the primary …
that occurs in the epithelial cells of the nasopharynx. Distant metastases are the primary …
[HTML][HTML] Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro …
EM Ploeg, DF Samplonius, X Xiong, X Ke… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory
extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory …
extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory …
[HTML][HTML] A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL
Transcriptional coactivators p300 and CBP catalyze the acetylation of lysine residues in
histone proteins. Upregulation of p300 and CBP has been associated with lung, colorectal …
histone proteins. Upregulation of p300 and CBP has been associated with lung, colorectal …
CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation
Receptor tyrosine kinases, such as VEGFR, PDGFR and EGFR, play important roles in renal
cancer. In this study, we investigated EGFR knockout as a therapeutic approach in renal cell …
cancer. In this study, we investigated EGFR knockout as a therapeutic approach in renal cell …
[HTML][HTML] HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway
Non-small-cell lung carcinoma (NSCLC) is one of the most common forms of lung cancer,
and a leading cause of cancer death among human beings. There is an urgent demand for …
and a leading cause of cancer death among human beings. There is an urgent demand for …
Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells
H Liu, Q Cheng, D Xu, W Wang, Z Fang, D Xue… - Respiratory …, 2020 - Springer
Background Under physiological conditions, CXCL12 modulates cell proliferation, survival,
angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered …
angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered …
CXC chemokine receptors in the tumor microenvironment and an update of antagonist development
Y Xun, H Yang, J Li, F Wu, F Liu - Reviews of Physiology, Biochemistry …, 2020 - Springer
Chemokine receptors, a diverse group within the seven-transmembrane G protein-coupled
receptor superfamily, are frequently overexpressed in malignant tumors. Ligand binding …
receptor superfamily, are frequently overexpressed in malignant tumors. Ligand binding …