The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

New chemotherapeutic drugs are the need to improve tuberculosis (TB) control particularly
due to the emergence of multidrug-resistant strains and extensively drug-resistant strains of …

The aims of this study were to develop proliposome powders containing isoniazid (INH) in a
dry powder aerosol form. INH-proliposome powders were prepared by a spray drying …

Tuberculosis and bacterial infections are major challenges because of elevated infection
rates and drug resistance. New chemical agents need to be developed to address them …

The needs of newly developed antitubercular agents are required for the control of
tuberculosis in the present time. In the discovery of new antitubercular drugs, the emergence …

Abstract Various 5-(fluoroaryl)-4-(hetero) aryl substituted pyrimidines have been synthesized
based on the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen …

The pyridazinone derivatives have diverse biological potential and are easily synthesized.
Due to this, researchers and chemists have paid attention to the design and development of …

The outer membrane (OM) of Gram-negative bacteria provides an efficient barrier against
external noxious compounds such as antimicrobial agents. Associated with drug target …

The success of the TB control program is hampered by the major issue of drug-resistant
tuberculosis (DR-TB). The situation has undoubtedly been made more difficult by the …

Tuberculosis is one of most pervasive, respiratory transmitted diseases and has spread to
every corner of the globe. According World Health Organization report, as much as one-third …