Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …

A large proportion of androgens in men (40%), and the majority of estrogens in women (75%
before menopause and close to 100% after menopause), are synthesized in peripheral …

The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Adrenal steroidogenesis is a dynamic process, reliant on de novo synthesis, with no
presynthesized hormones stored for immediate release. Cholesterol is the common …

Serum androgens as well as their precursors and metabolites decrease from the age of 30–
40 yr in women, thus suggesting that a more physiological hormone replacement therapy at …

A. Physiological and pharmacological significance B. Cloning and expression of the 3ß-
HSD/KSI cDNAs C. Structure, regulation, and tissue-specific expression of the 3ß-HSD/KSI …

A new understanding of the endocrinology of menopause is that women, at menopause, are
not only lacking estrogens resulting from cessation of ovarian activity but have also been …

We have recently reported that oocyte-derived bone morphogenetic protein-15 (BMP-15)
can directly modulate follicle-stimulating hormone (FSH) action in rat granulosa cells. Here …

Abstract The Arabidopsis DEETIOLATED2 (DET2) gene has been cloned and shown to
encode a protein that shares significant sequence identity with mammalian steroid 5 alpha …