The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …

An important challenge in mental health research is to translate findings from cognitive
neuroscience and neuroimaging research into effective treatments that target the …

Background Obsessive-compulsive disorder (OCD) is characterized by an excessive focus
on upsetting or disturbing thoughts, feelings, and images that are internally-generated …

The ability to assign safety to stimuli in the environment is integral to everyday functioning. A
key brain region for this evaluation is the ventromedial prefrontal cortex (vmPFC). To …

The most widely accepted model of obsessive–compulsive disorder (OCD) assumes brain
abnormalities in the “affective circuit”, mainly consisting of volume reduction in the medial …

Background Subtle deficits in executive functioning are present in patients with obsessive-
compulsive disorder (OCD) and their first-degree relatives, suggesting involvement of the …

Obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) are early-
onset disorders with significant overlapping phenomenology, especially in young patients …

Background: Obsessive–compulsive disorder (OCD) is a common, heritable
neuropsychiatric disorder, hypothetically underpinned by dysfunction of brain cortical …

Intrusive thoughts and compulsive urges to perform stereotyped behaviours are typical
symptoms of obsessive-compulsive disorder. Emerging evidence suggests a cognitive bias …

Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) are frequently
co-morbid, and dysfunctional frontal-striatal circuits have been implicated in both disorders …