Recent advances and applications of artificial intelligence in 3D bioprinting

H Chen, B Zhang, J Huang - Biophysics Reviews, 2024 - pubs.aip.org
3D bioprinting techniques enable the precise deposition of living cells, biomaterials, and
biomolecules, emerging as a promising approach for engineering functional tissues and …

[HTML][HTML] Medical Digital Twin: A Review on Technical Principles and Clinical Applications

M Tortora, F Pacchiano, SF Ferraciolli… - Journal of Clinical …, 2025 - mdpi.com
The usage of digital twins (DTs) is growing across a wide range of businesses. The health
sector is one area where DT use has recently increased. Ultimately, the concept of digital …

Mathematical model of clonal evolution proposes a personalised multi-modal therapy for high-risk neuroblastoma

M Italia, KY Wertheim, S Taschner-Mandl, D Walker… - Cancers, 2023 - mdpi.com
Simple Summary Neuroblastoma is a rare type of cancer that usually affects children. The
high-risk patients' expected survival rate is less than 50%. One reason is the lack of …

Effects of tumour heterogeneous properties on modelling the transport of radiative particles

VO Juma, D Sainz‐DeMena… - International Journal …, 2023 - Wiley Online Library
Dose calculation plays a critical role in radiotherapy (RT) treatment planning, and there is a
growing need to develop accurate dose deposition models that incorporate heterogeneous …

Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53

KY Wertheim, R Chisholm, P Richmond… - PLOS Computational …, 2024 - journals.plos.org
Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all
high-risk cases are expected to succumb to the disease even after chemotherapy, surgery …

Image-based biomarkers for engineering neuroblastoma patient-specific computational models

S Hervas-Raluy, D Sainz-DeMena… - Engineering with …, 2024 - Springer
Childhood cancer is a devastating disease that requires continued research and improved
treatment options to increase survival rates and quality of life for those affected. The …

[HTML][HTML] Patient-specific prostate tumour growth simulation: a first step towards the digital twin

Á Pérez-Benito, JM García-Aznar… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Prostate cancer (PCa) is a major world-wide health concern. Current diagnostic methods
involve Prostate-Specific Antigen (PSA) blood tests, biopsies, and Magnetic Resonance …

[HTML][HTML] A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma

C Borau, KY Wertheim, S Hervas-Raluy… - Computer Methods and …, 2023 - Elsevier
Neuroblastoma is a complex and aggressive type of cancer that affects children. Current
treatments involve a combination of surgery, chemotherapy, radiotherapy, and stem cell …

Harnessing multimodal clinical predictive models for childhood tumors

L Cerdá-Alberich, D Veiga-Canuto… - 2023 IEEE EMBS …, 2023 - ieeexplore.ieee.org
Neuroblastoma, the most common solid cancer in early childhood, exhibits significant
heterogeneity, ranging from benign to aggressive forms. This paper presents a …

New tools and methods to inform patient-specific cancer models

D Sainz De Mena, JM García Aznar, MÁ Pérez Ansón - zaguan.unizar.es
Cancer is a major global health challenge that requires the development of innovative tools
to improve our understanding and treatment of the disease. Patientspecific modeling has …