Ageing with HIV: Challenges and biomarkers

B Rodes, J Cadinanos, A Esteban-Cantos… - …, 2022 - thelancet.com
The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the
prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease …

[PDF][PDF] A potential role of the spike protein in neurodegenerative diseases: a narrative review

S Seneff, AM Kyriakopoulos, G Nigh, PA McCullough… - Cureus, 2023 - cureus.com
Human prion protein and prion-like protein misfolding are widely recognized as playing a
causal role in many neurodegenerative diseases. Based on in vitro and in vivo experimental …

Increased biomarkers of cardiovascular risk in HIV-1 viremic controllers and low persistent inflammation in elite controllers and art-suppressed individuals

DG Caetano, M Ribeiro-Alves, ED Hottz, LM Vilela… - Scientific Reports, 2022 - nature.com
HIV controllers (HICs) are models of HIV functional cure, although some studies have shown
persistent inflammation and increased rates of atherosclerosis in HICs. Since immune …

Recent advances in poor HIV immune reconstitution: what will the future look like?

W Zhang, L Ruan - Frontiers in Microbiology, 2023 - frontiersin.org
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing
viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected …

Comparative immune profiling in survivors of the 2023 Nipah outbreak in Kerala state, India

RR Sahay, HC Palav, AM Shete… - Journal of Medical …, 2024 - Wiley Online Library
Immune profiling of Nipah virus (NiV) infection survivors is essential for advancing our
understanding of NiV pathogenesis, improving diagnostic and therapeutic strategies, and …

Monocyte/macrophage-mediated innate immunity in HIV-1 infection: from early response to late dysregulation and links to cardiovascular diseases onset

E Teer, DE Joseph, RH Glashoff, M Faadiel Essop - Virologica Sinica, 2021 - Springer
Although monocytes and macrophages are key mediators of the innate immune system, the
focus has largely been on the role of the adaptive immune system in the context of human …

Dual antiretroviral therapy—all quiet beneath the surface?

BJ Van Welzen, PGA Oomen… - Frontiers in …, 2021 - frontiersin.org
Infection with the human immunodeficiency virus (HIV) is characterized by progressive
depletion of CD4+ lymphocytes cells as a result of chronic immune activation. Next to the …

Persistent inflammation and non-AIDS comorbidities during ART: coming of the age of monocytes

R Bai, Z Li, S Lv, R Wang, W Hua, H Wu… - Frontiers in …, 2022 - frontiersin.org
Monocytes are innate immune cells that serve as the first line of defense against pathogens
by engulfing and destroying pathogens or by processing and presenting antigens to initiate …

Inflammation markers and the risk of hypertension in people living with HIV

H Ou-Yang, HY Fu, Y Luo, ZY Xu, J Liu, R Gao… - Frontiers in …, 2023 - frontiersin.org
Background The incidence of hypertension is high in people living with HIV (PLWH). High-
sensitivity C-reactive protein (hsCRP), systemic inflammation response index (SIRI), and …

Viremic non-progression in HIV/SIV infection: A tied game between virus and host

Á Bayón-Gil, J Martinez-Picado, MC Puertas - Cell Reports Medicine, 2025 - cell.com
High-efficacy antiretroviral treatment (ART) has been a game-changer for HIV/AIDS
pandemic, but incomplete CD4+ T cell recovery and persistent chronic immune activation …