Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics
Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …
Carbonic anhydrases: An overview
A Nocentini, CT Supuran - Carbonic Anhydrases, 2019 - Elsevier
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the interconversion between CO 2
and bicarbonate as well as other hydrolytic reactions. Seven genetic families of CAs have …
and bicarbonate as well as other hydrolytic reactions. Seven genetic families of CAs have …
Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms
Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2. 1.1)
along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition …
along the gastrointestinal tract, including hCA II. The elucidation of the hormonal inhibition …
Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX
With an aim to develop novel potential antitumor agents, two series of benzene-and
benzothiazole-sulfonamide derivatives, acting as effective human carbonic anhydrase (hCA …
benzothiazole-sulfonamide derivatives, acting as effective human carbonic anhydrase (hCA …
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced …
A Nocentini, E Trallori, S Singh… - Journal of Medicinal …, 2018 - ACS Publications
Human carbonic anhydrases (CA, EC, 4.2. 1.1) IX and XII are overexpressed in cancer cells
as adaptive response to hypoxia and acidic conditions characteristic of many tumors. In …
as adaptive response to hypoxia and acidic conditions characteristic of many tumors. In …
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase …
In the presented work, we report the design and synthesis of different new sets of
triazolopyrimidine-based (9a-d) and triazole-based (11a-h, 13a-c, 15a, b, 17a, b and 21a-g) …
triazolopyrimidine-based (9a-d) and triazole-based (11a-h, 13a-c, 15a, b, 17a, b and 21a-g) …
Synthesis of novel isoindoline-1, 3-dione-based oximes and benzenesulfonamide hydrazones as selective inhibitors of the tumor-associated carbonic anhydrase IX
The synthesis, characterization and biological evaluation of a library of isoindoline-1, 3-
dione-based oximes and benzenesulfonamide hydrazones is disclosed. The set of …
dione-based oximes and benzenesulfonamide hydrazones is disclosed. The set of …
Investigation on hydrazonobenzenesulfonamides as human carbonic anhydrase I, II, IX and XII inhibitors
A small series of hydrazonobenzenesulfonamides was designed, synthesized and studied
for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds …
for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds …
Bioisosteric development of multitarget nonsteroidal anti-inflammatory drug–carbonic anhydrases inhibitor hybrids for the management of rheumatoid arthritis
S Bua, L Lucarini, L Micheli, M Menicatti… - Journal of Medicinal …, 2019 - ACS Publications
Multitarget nonsteroidal anti-inflammatory drug (NSAID)–carbonic anhydrase inhibitor (CAI)
agents for the management of rheumatoid arthritis are reported. The evidence of the plasma …
agents for the management of rheumatoid arthritis are reported. The evidence of the plasma …
Human carbonic anhydrases: tissue distribution, physiological role, and druggability
Fifteen different carbonic anhydrase (CA) isoforms have been identified and characterized in
human (h) so far, of which 12 are catalytically active and 3 lack activity (CA-related proteins) …
human (h) so far, of which 12 are catalytically active and 3 lack activity (CA-related proteins) …