How cells ensure correct repair of DNA double-strand breaks
J Her, SF Bunting - Journal of Biological Chemistry, 2018 - ASBMB
DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
DNA double-strand break repair pathway choice and cancer
T Aparicio, R Baer, J Gautier - DNA repair, 2014 - Elsevier
Since DNA double-strand breaks (DSBs) contribute to the genomic instability that drives
cancer development, DSB repair pathways serve as important mechanisms for tumor …
cancer development, DSB repair pathways serve as important mechanisms for tumor …
Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
DNA double-strand break (DSB) repair is essential for maintaining our genomes. Mre11-
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the …
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
H Khoury-Haddad, N Guttmann-Raviv… - Proceedings of the …, 2014 - National Acad Sciences
Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
demethylases are dysregulated in several types of cancer. Here, we reveal a previously …
Role of genomic instability in arsenic-induced carcinogenicity. A review
Exposure to chronic arsenic toxicity is associated with cancer. Although unstable genome is
a characteristic feature of cancer cells, the mechanisms leading to genomic instability in …
a characteristic feature of cancer cells, the mechanisms leading to genomic instability in …
PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
C Beck, C Boehler, J Guirouilh Barbat… - Nucleic acids …, 2014 - academic.oup.com
The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome
integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) …
integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) …
[HTML][HTML] Balancing DNA repair to prevent ageing and cancer
ER Stead, I Bjedov - Experimental Cell Research, 2021 - Elsevier
DNA damage is a constant stressor to the cell. Persistent damage to the DNA over time
results in an increased risk of mutation and an accumulation of mutations with age. Loss of …
results in an increased risk of mutation and an accumulation of mutations with age. Loss of …
NELF‐E is recruited to DNA double‐strand break sites to promote transcriptional repression and repair
SW Awwad, ER Abu‐Zhayia, N Guttmann‐Raviv… - EMBO …, 2017 - embopress.org
Double‐strand breaks (DSB s) trigger rapid and transient transcription pause to prevent
collisions between repair and transcription machineries at damage sites. Little is known …
collisions between repair and transcription machineries at damage sites. Little is known …
APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair
R Nowarski, OI Wilner, O Cheshin… - Blood, The Journal …, 2012 - ashpublications.org
APOBEC3 proteins catalyze deamination of cytidines in single-stranded DNA (ssDNA),
providing innate protection against retroviral replication by inducing deleterious dC> dU …
providing innate protection against retroviral replication by inducing deleterious dC> dU …
Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells
Double-strand break (DSB) repair pathways are critical for the maintenance of genomic
integrity and the prevention of tumorigenesis in mammalian cells. Here, we present the …
integrity and the prevention of tumorigenesis in mammalian cells. Here, we present the …