Update on the role and regulatory mechanism of extracellular matrix in the pathogenesis of uterine fibroids

Q Yang, A Al-Hendy - International Journal of Molecular Sciences, 2023 - mdpi.com
Uterine fibroids (UFs), also known as leiomyomas, are benign tumors of the myometrium
affecting over 70% of women worldwide, particularly women of color. Although benign, UFs …

Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy

Q Yang, OS Madueke-Laveaux, H Cun, M Wlodarczyk… - Cells, 2024 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …

A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell/tissue type-dependent action of sulforaphane

K Etoh, M Nakao - Journal of Biological Chemistry, 2023 - ASBMB
RNA sequencing (RNA-seq) is a powerful technique for understanding cellular state and
dynamics. However, comprehensive transcriptomic characterization of multiple RNA-seq …

Bromodomain-containing protein 9 regulates signaling pathways and reprograms the epigenome in immortalized human uterine fibroid cells

Q Yang, S Vafaei, A Falahati, A Khosh… - International journal of …, 2024 - mdpi.com
Bromodomain-containing proteins (BRDs) are involved in many biological processes, most
notably epigenetic regulation of transcription, and BRD dysfunction has been linked to many …

Empowering strategies for Lifestyle interventions, Diet modifications, and Environmental Practices for Uterine Fibroid Prevention; unveiling the LIFE UP awareness

S Vafaei, S Alkhrait, Q Yang, M Ali, A Al-Hendy - Nutrients, 2024 - mdpi.com
Uterine fibroids (UFs) are the most common prevalent benign tumor among women of
reproductive age, disproportionately affecting women of color. This paper introduces an …

[HTML][HTML] Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Q Yang, A Falahati, A Khosh, RR Lastra, TG Boyer… - Cells, 2024 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated
with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular …

Targeting Bromodomain-Containing Protein 9 in Human Uterine Fibroid Cells

Q Yang, A Falahati, A Khosh, S Vafaei… - Reproductive …, 2024 - Springer
Bromodomain (BRD)-containing proteins are evolutionarily conserved protein–protein
interaction modules involved in many biological processes. BRDs selectively recognize and …

Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator

D Karati, S Mukherjee, S Roy - Medical Oncology, 2024 - Springer
In developing new cancer medications, attention has been focused on novel epigenetic
medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer …

The Functional Role and Regulatory Mechanism of FTO m6A RNA Demethylase in Human Uterine Leiomyosarcoma

Q Yang, A Al-Hendy - International Journal of Molecular Sciences, 2023 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that
presents a poor prognosis and high rates of recurrence and metastasis. The origin and …