A roadmap for the clinical implementation of optical-imaging biomarkers

DJ Waterhouse, CRM Fitzpatrick, BW Pogue… - Nature biomedical …, 2019 - nature.com
Clinical workflows for the non-invasive detection and characterization of disease states
could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities …

Polarization-Sensitive Hyperspectral Imaging in vivo: A Multimode Dermoscope for Skin Analysis

F Vasefi, N MacKinnon, RB Saager, AJ Durkin… - Scientific reports, 2014 - nature.com
Attempts to understand the changes in the structure and physiology of human skin
abnormalities by non-invasive optical imaging are aided by spectroscopic methods that …

Hyperspectral and multispectral imaging in dermatology

F Vasefi, N MacKinnon, DL Farkas - Imaging in Dermatology, 2016 - Elsevier
The capacity of optical imaging methods to characterize biological tissue in general, and
skin in particular, with high resolution and discrimination ability provides a very valuable tool …

Biomedical Applications of Translational Optical Imaging: From Molecules to Humans

DL Farkas - Molecules, 2021 - mdpi.com
Light is a powerful investigational tool in biomedicine, at all levels of structural organization.
Its multitude of features (intensity, wavelength, polarization, interference, coherence, timing …

Three-dimensional representation of triple spectral line imaging data as an option for noncontact skin diagnostics

I Oshina, J Spigulis, I Kuzmina… - … of Biomedical Optics, 2022 - spiedigitallibrary.org
Significance: Skin malformations in dermatology are mostly evaluated subjectively, based
on a doctor's experience and visual perception; an option for objective quantitative skin …

Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy:(II) molecular mapping of highly pigmented lesions

F Vasefi, N MacKinnon… - Imaging, Manipulation, and …, 2014 - spiedigitallibrary.org
We have developed a multimode imaging dermoscope that combines polarization and
hyperspectral imaging with a computationally rapid analytical model. This approach …

Quantifying the optical properties of turbid media using polarization sensitive hyperspectral imaging (SkinSpect): Two-layer optical phantom studies

F Vasefi, N MacKinnon, R Saager… - … , and Analysis of …, 2015 - spiedigitallibrary.org
A polarization-sensitive hyperspectral imaging system (SkinSpect) has been built and
evaluated using two-layer tissue phantoms, fabricated to mimic the optical properties of …

Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy:(I) clinical system development and validation

N MacKinnon, F Vasefi… - Imaging, Manipulation, and …, 2014 - spiedigitallibrary.org
We introduce the new clinical prototype of SkinSpect–a multimode dermoscope combining
fluorescence, polarization and hyperspectral imaging. The system determines relative …

Towards real-time non contact spatial resolved oxygenation monitoring using a multi spectral filter array camera in various light conditions

JR Bauer, K Van Beekum, J Klaessens… - Optical Biopsy XVI …, 2018 - spiedigitallibrary.org
Non contact spatial resolved oxygenation measurements remain an open challenge in the
biomedical field and non contact patient monitoring. Although point measurements are the …

Quantifying the optical properties and chromophore concentrations of turbid media using polarization sensitive hyperspectral imaging: optical phantom studies

F Vasefi, R Saager, AJ Durkin… - … , and Analysis of …, 2013 - spiedigitallibrary.org
We present a polarization-sensitive hyperspectral imaging system (SkinSpect) that employs
a spectrally-programmable light source in the visible and NIR domains. Multiple tissue …