The role of artificial intelligence in early cancer diagnosis
B Hunter, S Hindocha, RW Lee - Cancers, 2022 - mdpi.com
Simple Summary Diagnosing cancer at an early stage increases the chance of performing
effective treatment in many tumour groups. Key approaches include screening patients who …
effective treatment in many tumour groups. Key approaches include screening patients who …
Integrated omics: tools, advances and future approaches
With the rapid adoption of high-throughput omic approaches to analyze biological samples
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …
Advances in the molecular genetics of gliomas—implications for classification and therapy
G Reifenberger, HG Wirsching… - Nature reviews Clinical …, 2017 - nature.com
Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …
alterations and epigenetic profiles associated with different types of gliomas. These …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
MYC dysregulation in the progression of multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy preceded by a premalignant stage,
named monoclonal gammopathy of undetermined significance (MGUS), and often a …
named monoclonal gammopathy of undetermined significance (MGUS), and often a …
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas
Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However,
TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less …
TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less …
Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing
P Euskirchen, F Bielle, K Labreche… - Acta …, 2017 - Springer
Molecular classification of cancer has entered clinical routine to inform diagnosis, prognosis,
and treatment decisions. At the same time, new tumor entities have been identified that …
and treatment decisions. At the same time, new tumor entities have been identified that …
CODEL: phase III study of RT, RT+ TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. Analysis from the initial study design
KA Jaeckle, KV Ballman, M Van Den Bent… - Neuro …, 2021 - academic.oup.com
Background We report the analysis involving patients treated on the initial CODEL design.
Methods Adults (> 18) with newly diagnosed 1p/19q World Health Organization (WHO) …
Methods Adults (> 18) with newly diagnosed 1p/19q World Health Organization (WHO) …
The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: How should they inform treatment decisions in the era of …
Abstract The 2016 and 2021 World Health Organization 2021 Classification of central
nervous system tumors have resulted in a major improvement in the classification of …
nervous system tumors have resulted in a major improvement in the classification of …