We conducted a narrative review of the literature to compare the pharmacological, efficacy
and safety profiles of tapentadol and tramadol, and to assess the clinical interest of …

Chronic kidney disease (CKD) is a global public health problem. Pain is one of the most
generally experienced symptoms by CKD patients. Pain management is a key clinical …

Emergency or postoperative pain often represents an authentic challenge in patients who
were already on opioid treatment for chronic pain. Thus, their management requires not only …

Methods and Results To explore a better treatment, we collected exosomes from pluripotent
stem cell (PSC)-derived mesenchymal stem cells (MSC) and verified their therapeutic effect …

A recent Pro-Con article1 and an accompanying editorial2 bring to the fore the use of
methadone in the perioperative period. This is timely and important. Methadone is frequently …

Extended‐release opioids are often prescribed to manage postoperative pain despite being
difficult to titrate to analgesic requirements and their association with long‐term opioid use …

The prevalence of chronic pain in patients with chronic kidney disease (CKD) and diabetes
mellitus is high and correlates with higher frailty risk, but satisfactory pain control frequently …

Objective: Despite treatment advances over the past 30 years, the societal impact of hard-to-
heal wounds is increasingly burdensome. An unresolved issue is wound pain, which can …

Background: Across Canada, opioid-related hospitalizations, emergency department visits,
and mortality have increased. A literature gap exists related to opioid prescribing and safety …

Background Chronic pain significantly impacts quality of life and poses substantial public
health challenges. Buprenorphine, a synthetic analog of thebaine, is recognized for its …