The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

This study describes the occurrence of renal failure among 1353 newly diagnosed cases of
multiple myeloma. Renal function was evaluated by serum creatinine concentration in 1353 …

Motivation: Protein structure similarity is often measured by root mean squared deviation,
global distance test score and template modeling score (TM-score). However, the scores …

Structure comparison opens a window into the distant past of protein evolution, which has
been unreachable by sequence comparison alone. With 55000 entries in the Protein Data …

Familial hypercholesterolemia (FH) is caused predominately by variants in the low‐density
lipoprotein receptor gene (LDLR). We report here an update of the UCL LDLR variant …

Detection, comparison and analyses of binding pockets are pivotal to structure-based drug
design endeavors, from hit identification, screening of exosites and de-orphanization of …

The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted
protein structures composed of domains, which are independently folding units found in …

Abstract The Protein Data Bank archive was established in 1971, and recently celebrated its
40th anniversary (Berman et al. in Structure 20: 391, 2012). An analysis of interrelationships …

Allostery is the most direct, rapid and efficient way of regulating protein function, ranging
from the control of metabolic mechanisms to signal-transduction pathways. However, an …

The characteristics of heme prosthetic groups and their binding sites have been analyzed in
detail in a data set of nonhomologous heme proteins. Variations in the shape, volume, and …