Publisher Summary This chapter investigates the anatomy and taxonomy of protein
structures. A protein is a polypeptide chain made up of amino acid residues linked together …

Monoclonal antibodies can now be genetically engineered and endowed with new
properties. In the future, gene technology could enable antigen-binding fragments to be …

We have analysed the atomic structures of Fab and VL fragments of immunoglobulins to
determine the relationship between their amino acid sequences and the three-dimensional …

The variable domains of an antibody consist of a β-sheet framework with hypervariable
regions (or complementarity-determining regions—CDRs) which fashion the antigen …

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six
hypervariable regions from the heavy-and light-chain variable domains of a rat antibody …

A biosynthetic antibody binding site, which incorporated the variable domains of anti-digoxin
monoclonal antibody 26-10 in a single polypeptide chain (Mr= 26,354), was produced in …

Novel methods for producing, and compositions of, humanized immunoglobulins having one
or more complementarity determining regions (CDR's) and possible additional amino acids …

The database of known protein three‐dimensional structures can be significantly increased
by the use of sequence homology, based on the following observations.(1) The database of …

The remarkable progress in engineering and clinical development of therapeutic antibodies
in the last 40 years, after the seminal work by Köhler and Milstein, has led to the approval by …

The three-dimensional structure of the human histocompatibility antigen HLA-A2 was
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …