Virulence-associated enzymes of Cryptococcus neoformans
F Almeida, JM Wolf, A Casadevall - Eukaryotic cell, 2015 - Am Soc Microbiol
Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …
activity can significantly alter the infection process, and enzyme expression profiles can be a …
Calcineurin-Crz1 signaling in lower eukaryotes
S Thewes - Eukaryotic cell, 2014 - Am Soc Microbiol
Calcium ions are ubiquitous intracellular messengers. An increase in the cytosolic Ca2+
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …
concentration activates many proteins, including calmodulin and the Ca2+/calmodulin …
Calcium signaling is involved in diverse cellular processes in fungi
ABSTRACT Calcium (Ca2+) is a universal signalling molecule of life. The Ca2+ signalling is
an evolutionarily conserved process from prokaryotes to eukaryotes. Ca2+ at high …
an evolutionarily conserved process from prokaryotes to eukaryotes. Ca2+ at high …
The tools for virulence of Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP)
are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never …
are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never …
Cryptococcus: History, Epidemiology and Immune Evasion
Cryptococcosis is a disease caused by the pathogenic fungi Cryptococcus neoformans and
Cryptococcus gattii, both environmental fungi that cause severe pneumonia and may even …
Cryptococcus gattii, both environmental fungi that cause severe pneumonia and may even …
IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …
signaling pathway is critical for virulence. We recently demonstrated the key role of the …
Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A
Abstract Background The pathogenic yeast Cryptococcus neoformans causes life-
threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic …
threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic …
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence
Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol
pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans …
pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans …
Microbial inositol polyphosphate metabolic pathway as drug development target
Inositol polyphosphates are a diverse and multifaceted class of intracellular messengers
omnipresent in eukaryotic cells. These water-soluble molecules regulate many aspects of …
omnipresent in eukaryotic cells. These water-soluble molecules regulate many aspects of …