In less than 10 years, melanoma treatment has been revolutionized with the approval of
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …

Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

We previously reported a genome-wide association study (GWAS) identifying 14
susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals …

Skin aging is accompanied by a gradual loss of function, physiological integrity and the
ability to cope with internal and external stressors. This is secondary to a combination of …

Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning,
vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing …

The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Indoor tanning (sunbeds, solarium) uses artificial ultraviolet radiation (UVR) to stimulate
cosmetic tanning of the skin. Indoor tanning has been officially classified as a human …

The skin is a barrier between the internal and external environment of an organism.
Depending on the species, it participates in multiple functions. The skin is the organ that …

Recent advances in the chemistry of melanins have begun to disclose a number of important
structure-property-function relationships of crucial relevance to the biological role of human …