Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …

Data-driven modeling directly utilizes experimental data with machine learning techniques
to predict a material's response without the necessity of using phenomenological constitutive …

High-fidelity cardiac models using attribute-rich finite element based models have been
developed to a very mature stage. However, such finite-element based approaches remain …

Degenerative mitral valve disease is the main cause of primary mitral regurgitation with two
phenotypes: fibroelastic deficiency (FED) often with localized myxomatous degeneration …

The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …

The function of right ventricle (RV) is recognized to play a key role in the development of
many cardiopulmonary disorders, such as pulmonary arterial hypertension (PAH). Given the …

Disorganization of the valve extracellular matrix (ECM) is a hallmark of calcific aortic valve
disease (CAVD). However, while microarchitectural features of the ECM can strongly …

Given the functional complexities of soft tissues and organs, it is clear that computational
simulations are critical in their understanding and for the rational basis for the development …

Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …