Although, better known for its role in inflammation, the transcription factor nuclear factor
kappa B (NF-κB) has more recently been implicated in synaptic plasticity, learning, and …

Background Life is a constant flow of electrons via redox couples. Redox reactions
determine many if not all major cellular functions. Until recently, redox processes remained …

The innate immune system is the first line of host defense, and it is capable of resisting both
exogenous pathogenic challenges and endogenous danger signals via different pattern …

Electrical stimulation (ES)-triggered up-regulation of brain-derived neurotrophic factor
(BDNF) and neurite outgrowth in cultured rat postnatal dorsal root ganglion neurons …

Abstract Significance: Hydrogen peroxide (H2O2) is not only a key mediator of oxidative
stress but also one of the most important cellular second messengers. This small short-lived …

Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …

Background: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic
growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; …

Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents
of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function …

Ryanodine receptors (RyR) amplify activity-dependent calcium influx via calcium-induced
calcium release. Calcium signals trigger postsynaptic pathways in hippocampal neurons …

The expression of several hippocampal genes implicated in learning and memory
processes requires that Ca2+ signals generated in dendritic spines, dendrites, or the soma …