Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance

Y Bozzi, G Provenzano… - European Journal of …, 2018 - Wiley Online Library
Autism spectrum disorders (ASD) and epilepsy are common neurological diseases of
childhood, with an estimated incidence of approximately 0.5–1% of the worldwide …

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury

CL Eastman, R D'Ambrosio, T Ganesh - Neuropharmacology, 2020 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

U Pfisterer, V Petukhov, S Demharter… - Nature …, 2020 - nature.com
Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …

Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

BP Tewari, L Chaunsali, SL Campbell, DC Patel… - Nature …, 2018 - nature.com
Brain tumor patients commonly present with epileptic seizures. We show that tumor-
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …

Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy

E Cho, J Kwon, G Lee, J Shin, H Lee, SH Lee… - Nature …, 2024 - nature.com
Focal cortical dysplasia type I (FCD I) is the most common cause of pharmaco-resistant
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …

Parvalbumin role in epilepsy and psychiatric comorbidities: from mechanism to intervention

LD Godoy, T Prizon, MT Rossignoli, JP Leite… - Frontiers in Integrative …, 2022 - frontiersin.org
Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model

AA Khan, T Shekh‐Ahmad, A Khalil… - British journal of …, 2018 - Wiley Online Library
Background and Purpose A non‐psychoactive phytocannabinoid, cannabidiol (CBD), shows
promising results as an effective potential antiepileptic drug in some forms of refractory …

Medial prefrontal cortex circuitry and social behaviour in autism

DH Mediane, S Basu, EN Cahill, PG Anastasiades - Neuropharmacology, 2024 - Elsevier
Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its
underlying genetic causes and the huge variability in symptom presentation. Uncovering …

Toxoplasma infection induces microglia‐neuron contact and the loss of perisomatic inhibitory synapses

GL Carrillo, VA Ballard, T Glausen, Z Boone, J Teamer… - Glia, 2020 - Wiley Online Library
Infection and inflammation within the brain induces changes in neuronal connectivity and
function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that …

Interneuronopathies and their role in early life epilepsies and neurodevelopmental disorders

AM Katsarou, SL Moshé, AS Galanopoulou - Epilepsia open, 2017 - Wiley Online Library
GABA ergic interneurons control the neural circuitry and network activity in the brain. The
advances in genetics have identified genes that control the development, maturation, and …