The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to
fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia …

Recent discoveries of basal extracellular Rickettsiales have illuminated divergent
evolutionary paths to host dependency in later-evolving lineages. Family Rickettsiaceae …

The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

In adapting to the intracellular niche, obligate intracellular bacteria usually undergo a
reduction of genome size by eliminating genes not needed for intracellular survival. These …

Background Scrub typhus is a vector-borne febrile illness caused by Orientia tsutsugamushi
transmitted by the bite of Trombiculid mites. O. tsutsugamushi has a high genetic diversity …

The rickettsial human pathogen Orientia tsutsugamushi (Ot) is an obligate intracellular Gram-
negative bacterium with one of the most highly fragmented and repetitive genomes of any …

Orientia tsutsugamushi is the etiologic agent of scrub typhus, the deadliest of all diseases
caused by obligate intracellular bacteria. Nucleomodulins, bacterial effectors that …

Cheap, rapid, simple and equipment-free nucleic acid extraction (NAE) is highly preferred
for implementing nucleic acid detection at point-of-care (POC). Paper-based NAE materials …