Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Aquaporin water channels in the nervous system

MC Papadopoulos, AS Verkman - Nature Reviews Neuroscience, 2013 - nature.com
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

The water transport system in astrocytes–Aquaporins

Z Zhou, J Zhan, Q Cai, F Xu, R Chai, K Lam, Z Luan… - Cells, 2022 - mdpi.com
Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

[HTML][HTML] Key roles of aquaporins in tumor biology

MC Papadopoulos, S Saadoun - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Aquaporins are protein channels that facilitate the flow of water across plasma cell
membranes in response to osmotic gradients. This review summarizes the evidence that …

Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract

G Farrugia, JH Szurszewski - Gastroenterology, 2014 - Elsevier
Carbon monoxide (CO) and hydrogen sulfide (H 2 S) used to be thought of simply as lethal
and (for H 2 S) smelly gaseous molecules; now they are known to have important signaling …

Aquaporin and brain diseases

J Badaut, AM Fukuda, A Jullienne, KG Petry - Biochimica et Biophysica …, 2014 - Elsevier
Background The presence of water channel proteins, aquaporins (AQPs), in the brain led to
intense research in understanding the underlying roles of each of them under normal …

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

DB Kell, N Swainston, P Pir, SG Oliver - Trends in biotechnology, 2015 - cell.com
Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?

REF Turner, H Gatterer, M Falla… - Journal of Applied …, 2021 - journals.physiology.org
High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Aquaporins as diagnostic and therapeutic targets in cancer: how far we are?

J Wang, L Feng, Z Zhu, M Zheng, D Wang… - Journal of translational …, 2015 - Springer
Aquaporins (AQPs) are a family of water channel proteins distributed in various human
tissues, responsible for the transport of small solutes such as glycerol, even gas and ions …

Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …