Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants

H Daniell, SJ Streatfield, K Wycoff - Trends in plant science, 2001 - cell.com
The use of plants for medicinal purposes dates back thousands of years but genetic
engineering of plants to produce desired biopharmaceuticals is much more recent. As the …

Plant cell cultures for the production of recombinant proteins

S Hellwig, J Drossard, RM Twyman, R Fischer - Nature biotechnology, 2004 - nature.com
The use of whole plants for the synthesis of recombinant proteins has received a great deal
of attention recently because of advantages in economy, scalability and safety compared …

Plant‐made vaccines for humans and animals

EP Rybicki - Plant biotechnology journal, 2010 - Wiley Online Library
The concept of using plants to produce high‐value pharmaceuticals such as vaccines is 20
years old this year and is only now on the brink of realisation as an established technology …

Molecular farming of pharmaceutical proteins

R Fischer, N Emans - Transgenic research, 2000 - Springer
Molecular farming is the production of pharmaceutically important and commercially
valuable proteins in plants. Its purpose is to provide a safe and inexpensive means for the …

Foreign protein production in plant tissue cultures

PM Doran - Current Opinion in Biotechnology, 2000 - Elsevier
Foreign proteins synthesised by plants are now in the marketplace, and clinical trials for
plant-derived therapeutic proteins are underway. Economic analysis of plant production …

Preventing unintended proteolysis in plant protein biofactories

M Benchabane, C Goulet, D Rivard… - Plant biotechnology …, 2008 - Wiley Online Library
Numerous reports have been published over the last decade assessing the potential of
plants as useful hosts for the heterologous expression of clinically useful proteins …

Transgenic animal bioreactors

LM Houdebine - Transgenic research, 2000 - Springer
The production of recombinant proteins is one of the major successes of biotechnology.
Animal cells are required to synthesize proteins with the appropriate post-translational …

Practical considerations for pharmaceutical antibody production in different crop systems

E Stoger, M Sack, Y Perrin, C Vaquero, E Torres… - Molecular …, 2002 - Springer
The potential of plant cells to produce functional recombinantantibodies has been
demonstrated in a number of different plant systems. Wepresent a comparative study of a …

Generation and production of engineered antibodies

SM Kipriyanov, F Le Gall - Molecular biotechnology, 2004 - Springer
Various forms of recombinant monoclonal antibodies are being used increasingly, mainly for
therapeutic purposes. This review specifically focuses on what is now called antibody …

Molecular farming of recombinant antibodies in plants

S Schillberg, R Fischer, N Emans - Cellular and Molecular Life Sciences …, 2003 - Springer
Antibodies represent a large proportion of therapeutic drugs currently in development. In
most cases, they are produced in mammalian cell lines or transgenic animals because these …