Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Cells produce multiple mRNAs through alternative splicing, which ensures proteome
diversity. Because most human genes undergo alternative splicing, key components of …

Hedgehog signaling is activated in response to liver injury, and modulates organogenesis.
However, the role of non-canonical hedgehog activation via TGF-β1/SMAD3 in hepatic …

Cancer invasion and metastasis accounts for the majority of cancer related mortality. A better
understanding of the players that drive the aberrant invasion and migration of tumors cells …

Alternative splicing (AS) produces the different mRNA splicing bodies, which are then
translated into multiple protein isoforms and participate in various biological functions. With …

The prognosis of elderly AML patients is still poor due to chemotherapy resistance. The
Hedgehog (HH) pathway is important for leukemic transformation because of aberrant …

Summary Context The Gli‐family of zinc‐finger transcription factors regulates the Sonic
Hedgehog (Shh) signalling pathway that plays a key role in early pituitary and ventral …

Papillary thyroid carcinoma (PTC) is a common malignancy in thyroid tissue. However, the
molecular mechanism of PTC tumor progression remains unknown. The hedgehog (Hh) …

Background The prevalence of respiratory allergy in children is increasing. Epigenetic DNA
methylation changes are plausible underlying molecular mechanisms. Results Saliva …