The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …

Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …

The transplanting islets to the liver approach suffers from an immediate posttransplant loss
of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery …

Type 1 diabetes mellitus is a chronic metabolic condition characterized by the autoimmune
damage of pancreatic β cells. As an alternative to continuous exogenous insulin …

Islet transplantation has now become a promising treatment for insulin-deficient diabetes
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …

Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes
mellitus is severely hampered by the requirement for continuous immunosuppression and its …

Islet transplantation may provide a prospective treatment for type 1 diabetes. To enable islet
transplantation and restore autonomous glucose monitoring and insulin secretion, islets or β …