2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile
biological profiles, a simple structure, and mild adverse effects. Researchers discovered …

Chromene is commonly found in nature and is considered one of the most frequently used
scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and …

Sulfonamides have been in clinical use for many years, and the development of bioactive
substances containing the sulfonamide subunit has grown steadily in view of their important …

Main observation and conclusion The limit ability of traditional antibiotics to treat drug
resistant bacteria calls for new therapeutic alternatives. A class of unique sulfanilamide …

Novel series of diazepam bearing sulfonamide moieties 5 af and 7 ac were designed,
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …

A new series of sulfonamide endowed with hydrazone coupled to dimethyl and/or diethyl
malonates were prepared. Various sulfa drugs were diazotized and followed by coupling …

Thirty-one new 4 H-chromene derivatives were designed and synthesized. Their structures
were identified with IR, 1H NMR, 13C NMR, and HRMS. The crystal structure of compound …

This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …

The aim of this work is to present results of both experimental and theoretical studies of 2–
thioxo–3–N,(4–methylphenyl) thiazolidine–4–one. In this paper, we present the chemical …

Microbiological DNA gyrase is recognized as an exceptional microbial target for the
innovative development of low-resistant and more effective antimicrobial drugs. Hence, we …