A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role
not only in the physiological processes associated with reward and satisfaction but also in …

New psychoactive substances (NPS) with amphetamine-, aminoindan-, and benzofuran
basic chemical structures have recently emerged for recreational drug use. Detailed …

Compulsive drug use despite adverse consequences defines addiction. While mesolimbic
dopamine signaling is sufficient to drive compulsion, psychostimulants such as cocaine also …

Aberrant dopamine (DA) signalling has been implicated in various neuropsychiatric
disorders, including attention‐deficit/hyperactivity disorder (ADHD), autism spectrum …

The G protein-coupled receptor 52 (GPR52) is an orphan receptor that is selectively
expressed in the striatum and regulates various brain functions through activation of cAMP …

Tropane alkaloids are an important class of biologically active small molecules
characterized by their 8-azabicyclo [3.2. 1] octane core. Because of their numerous …

The benefits of opioid-based treatments to mitigate chronic pain can be hindered by the side
effects of opioid-induced hyperalgesia (OIH) that can lead to higher consumption and risk of …

Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by
a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and …

Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a
significant health concern. Illicit substances are taken by healthy individuals as well as by …

The orbitofrontal cortex (OFC) is a brain region involved in higher-order decision-making.
Rodent studies show that cocaine self-administration (CSA) reduces OFC contribution to …