Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It
combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 …

The possibility of exploiting the analytical power of mass spectrometry to image the
chemistry of biological and similarly complex materials without the use of tags and with good …

This completely revised and expanded new edition covers the full range of techniques now
available for the investigation of materials structure and accurate quantitative determination …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is an established technique for
the characterization of solid sample surfaces. The introduction of polyatomic ion beams …

An analysis is made of the sputtering yields of materials for argon gas cluster ion beams
used in SIMS and XPS as a function of the beam energy, E, and the cluster size, n. The …

The depth profiling of organic materials with argon cluster ion sputtering has recently
become widely available with several manufacturers of surface analytical instrumentation …

Gas cluster ion beams (GCIBs) provide new opportunities for bioimaging and molecular
depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of …

Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …