The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …

Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in
yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding …

The biogenesis of eukaryotic ribosomes is a complicated process during which the
transcription, modification, folding, and processing of the rRNA is coupled with the ordered …

Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in
a highly coordinated manner. More than 200 factors ensure correct modification, processing …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

RNA folds into intricate structures that enable its pivotal roles in biology, ranging from
regulation of gene expression to ligand sensing and enzymatic functions. Therefore …