Over the past decade, the focus of research into the pathophysiology of mood disorders
(bipolar disorder and unipolar depression in particular) has shifted from an interest in the …

Considerable attention has recently been paid to astrocyte functions, which are briefly
summarized. A large amount of data is available about adrenoceptor expression and …

INTRODUCCIÓN: La depresión mayor (DM) se debe a la interacción de factores
ambientales, genéticos y epigenéticos, que atenúan la transmisión monoaminérgica en el …

Over the past four decades, a variety of interventions have been used for the treatment of
clinical depression and other affective disorders. Several distinct pharmacological …

The mode of action of antidepressant drugs may be related to mechanisms of monoamines
receptor adaptation, including serotonin 5‐HT4 receptor subtypes. Here we investigated the …

Progress toward new antidepressant therapies has been relatively slow over the past few
decades, with the result that individuals suffering from depression often struggle to find an …

Objective To determine whether the currently available evidence supports the hypothesis
that antidepressants and mood stabilizers may bring about some of their long-term …

Previous studies demonstrated that Gsα migrates from a Triton X-100 (TTX-100) insoluble
membrane domain to a TTX-100 soluble membrane domain in response to chronic …

Results from previous studies suggested that chronic treatment of rats or C6 glioma cells
with antidepressants augments the coupling between Gs and adenylyl cyclase. As these …

The underlying molecular mechanism of action of lithium in the treatment of manic-
depressive illness is not clear. The effect of chronic lithium on GTP-binding and toxin …