Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Simple Summary Solitary fibrous tumor (SFT) is a malignant condition that exhibits different
clinical behaviors ranging from low to high aggressive SFT, with dedifferentiated SFT (DD …

Background The addition of trabectedin to doxorubicin, followed by trabectedin
maintenance, may have superior efficacy to doxorubicin alone as first-line treatment in …

The remit of this guideline is to collate and propose evidence-based guidelines for the
diagnosis and management of uterine cancer. This document covers all uterine cancers of …

Abstract Background Soft-tissue sarcomas (STSs) are rare malignancies, accounting for
approximately 1% of adult cancer. Metastatic disease carries a poor prognosis, and various …

Background Metastatic leiomyosarcomas have a poor prognosis, and currently doxorubicin
alone is used as the standard first-line treatment. Doxorubicin combined with trabectedin …

Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Anthracyclines have contributed significantly to remarkable improvements in overall survival
and are regarded as the most effective cytostatic drug for cancer treatment in various …

Abstract PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this
paper, we present an open-label, non-randomized, non-comparative pilot study of …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …