Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

A Santoro, E Bientinesi, D Monti - Ageing research reviews, 2021 - Elsevier
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

H Peckham, NM de Gruijter, C Raine… - Nature …, 2020 - nature.com
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes …

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

N Sayed, Y Huang, K Nguyen, Z Krejciova-Rajaniemi… - Nature aging, 2021 - nature.com
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Considering how biological sex impacts immune responses and COVID-19 outcomes

EP Scully, J Haverfield, RL Ursin… - Nature Reviews …, 2020 - nature.com
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …

Sex differences in severity and mortality from COVID-19: are males more vulnerable?

A Pradhan, PE Olsson - Biology of sex Differences, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates
all over the world, and despite the global efforts, there is so far no specific therapy available …

Sex differences in immunity to viral infections

H Jacobsen, SL Klein - Frontiers in immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences
in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias …

Factors that influence the immune response to vaccination

P Zimmermann, N Curtis - Clinical microbiology reviews, 2019 - Am Soc Microbiol
There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …

Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine

R Pellini, A Venuti, F Pimpinelli, E Abril… - …, 2021 - thelancet.com
Background Literature data suggests that age, gender and body mass index (BMI) could be
associated with difference in immune responses to vaccines. The first goal of the study was …

Human immune diversity: from evolution to modernity

A Liston, S Humblet-Baron, D Duffy, A Goris - Nature immunology, 2021 - nature.com
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …