Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that
are related to the construction and refinement of functional networks. During the …

▪ Abstract Many pathways in the developing visual system are restructured and become
highly organized even before vision occurs. Yet the developmental processes underlying …

The mammalian retina conveys the vast majority of information about visual stimuli to two
brain regions: the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) …

The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …

During retinocollicular map development, spontaneous waves of action potentials spread
across the retina, correlating activity among neighboring retinal ganglion cells (RGCs). To …

Gradients of axon guidance molecules have long been postulated to control the
development of the organization of neural connections into topographic maps. We review …

Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but
it remains unclear how such activity instructs axonal connectivity with subcellular precision …

Abstract Ephrin-A2 and-A5 are thought to be anteroposterior mapping labels for the
retinotectal/retinocollicular projection. Here, gene disruptions of both these ephrins are …

Abstract Ephrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal
axons in vitro and has a graded expression in the superior colliculus (SC), the major …

We demonstrate a rapid and complex effect of N-methyl-d-aspartate receptor (NMDAR)
activation on synaptic protein synthesis in the superior colliculi of young rats. Within minutes …