Oxidative stress during HIV infection: mechanisms and consequences

AV Ivanov, VT Valuev-Elliston… - Oxidative medicine …, 2016 - Wiley Online Library
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …

Modern methods for delivery of drugs across the blood–brain barrier

Y Chen, L Liu - Advanced drug delivery reviews, 2012 - Elsevier
The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

Characteristics of compounds that cross the blood-brain barrier

WA Banks - BMC neurology, 2009 - Springer
Substances cross the blood-brain barrier (BBB) by a variety of mechanisms. These include
transmembrane diffusion, saturable transporters, adsorptive endocytosis, and the …

Nanoscale drug delivery systems and the blood–brain barrier

R Alyautdin, I Khalin, MI Nafeeza… - International journal …, 2014 - Taylor & Francis
The protective properties of the blood–brain barrier (BBB) are conferred by the intricate
architecture of its endothelium coupled with multiple specific transport systems expressed on …

Viral infection of the central nervous system and neuroinflammation precede blood-brain barrier disruption during Japanese encephalitis virus infection

F Li, Y Wang, L Yu, S Cao, K Wang, J Yuan… - Journal of …, 2015 - Am Soc Microbiol
Japanese encephalitis is an acute zoonotic, mosquito-borne disease caused by Japanese
encephalitis virus (JEV). Japanese encephalitis is characterized by extensive inflammation …

Tight junction in blood‐brain barrier: an overview of structure, regulation, and regulator substances

WY Liu, ZB Wang, LC Zhang, X Wei… - CNS neuroscience & …, 2012 - Wiley Online Library
Blood‐brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic
substance in and out of the central nervous system (CNS), and plays a crucial role in …

Blood–brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy

BS Desai, AJ Monahan, PM Carvey… - Cell …, 2007 - journals.sagepub.com
The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system.
Though the BBB is thought to be intact during neurodegenerative diseases such as …

Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier

MA Erickson, K Dohi, WA Banks - Neuroimmunomodulation, 2012 - karger.com
The blood-brain barrier (BBB) is not simply a physical barrier but a regulatory interface
between the central nervous system (CNS) and immune system. The BBB both affects and is …

Neuroinvasion and inflammation in viral central nervous system infections

T Dahm, H Rudolph, C Schwerk… - Mediators of …, 2016 - Wiley Online Library
Neurotropic viruses can cause devastating central nervous system (CNS) infections,
especially in young children and the elderly. The blood‐brain barrier (BBB) and the blood …

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

AV Kabanov, HE Gendelman - Progress in polymer science, 2007 - Elsevier
Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's
diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's …