Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Cardiac injury leads to the loss of cardiomyocytes, which are rapidly replaced by the
proliferation of the surviving cells in zebrafish, but not in mammals. In both the regenerative …

Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

Myocardial infarction (MI) is a pathological process, evidencing as massive death of
cardiomyocytes associated with hypoxic and oxidative stress. The formation of areas of …

Unlike humans and other mammals, zebrafish demonstrate a remarkable capacity to
regenerate their injured hearts throughout life. Mitochondrial fatty acid β-oxidation (FAO) …

Abstract Congenital Heart Disease (CHD), malformations of the heart present at birth, is the
most common class of life-threatening birth defect (Hoffman (1995)[1], Gelb (2004)[2], Gelb …

In humans, myocardial infarction results in ventricular remodeling, progressing ultimately to
cardiac failure, one of the leading causes of death worldwide. In contrast to the adult …

Accurate monitoring of cardiomyocyte action potentials (APs) is essential to understand
disease propagation and for trials of novel therapeutics. Patch clamp techniques offer 'gold …

Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after
injury. Previous study has shown Notch signaling activation in the endocardium is essential …