Microbial biofilm: a review on formation, infection, antibiotic resistance, control measures, and innovative treatment

S Sharma, J Mohler, SD Mahajan, SA Schwartz… - Microorganisms, 2023 - mdpi.com
Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide
matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to …

Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Staphylococcal biofilms

M Otto - Microbiology spectrum, 2018 - Am Soc Microbiol
Staphylococci, with the leading species Staphylococcus aureus and Staphylococcus
epidermidis, are the most frequent causes of infections on indwelling medical devices. The …

Bacterial extracellular polysaccharides in biofilm formation and function

DH Limoli, CJ Jones, DJ Wozniak - Microbial Biofilms, 2015 - Wiley Online Library
The ability to construct and maintain a structured multicellular bacterial community depends
critically on the production of extracellular matrix components (1, 2). While the biofilm matrix …

Coagulase-negative staphylococci

K Becker, C Heilmann, G Peters - Clinical microbiology reviews, 2014 - Am Soc Microbiol
The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is
still based on diagnostic procedures that fulfill the clinical need to differentiate between …

Polysaccharide intercellular adhesin in biofilm: structural and regulatory aspects

CR Arciola, D Campoccia, S Ravaioli… - Frontiers in cellular and …, 2015 - frontiersin.org
Staphylococcus aureus and Staphylococcus epidermidis are the leading etiologic agents of
implant-related infections. Biofilm formation is the main pathogenetic mechanism leading to …

Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials

CR Arciola, D Campoccia, P Speziale, L Montanaro… - Biomaterials, 2012 - Elsevier
Implant infections in orthopaedics, as well as in many other medical fields, are chiefly
caused by staphylococci. The ability of growing within a biofilm enhances the chances of …

[HTML][HTML] The staphylococcal exopolysaccharide PIA–Biosynthesis and role in biofilm formation, colonization, and infection

HTT Nguyen, TH Nguyen, M Otto - Computational and Structural …, 2020 - Elsevier
Exopolysaccharide is a key part of the extracellular matrix that contributes to important
mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion …

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

D Lebeaux, A Chauhan, O Rendueles, C Beloin - Pathogens, 2013 - mdpi.com
The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …

The role of microbial biofilms in prosthetic joint infections: A review

HO Gbejuade, AM Lovering, JC Webb - Acta orthopaedica, 2015 - Taylor & Francis
Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted
rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise …