In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where
invaginations of the surface membrane (t-tubules) form functional junctions with the …

The effects of the immunophilins, FKBP12 and FKBP12. 6, and phosphorylation on type II
ryanodine receptor (RyR2) arrangement and function were examined using correlation …

Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …

Key points Using 3D direct stochastic optical reconstruction microscopy (dSTORM), we
developed novel approaches to quantitatively describe the nanoscale, 3D organization of …

Ca2+ sparks constitute the fundamental units of Ca2+ release in cardiomyocytes. Here we
investigate how ryanodine receptors (RyRs) collectively generate these events by …

Aims It is unknown how β‐adrenergic stimulation affects calcium dynamics in individual
RyR2 clusters and leads to the induction of spontaneous calcium waves. To address this, we …

During chronic stress, persistent activation of cAMP-dependent protein kinase (PKA) occurs,
which can contribute to protective or maladaptive changes in the heart. We sought to …

Abstract L-type Ca V 1.2 channels are key regulators of gene expression, cell excitability
and muscle contraction. Ca V 1.2 channels organize in clusters throughout the plasma …

Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular
machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical …