Current treatment of metastatic endometrial cancer

SM Temkin, G Fleming - Cancer Control, 2009 - journals.sagepub.com
Background Endometrial cancer is the most common gynecologic malignancy. The majority
of patients have disease confined to the uterus and have an excellent overall prognosis …

Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted …

A Gadducci, S Cosio, AR Genazzani - Critical reviews in oncology …, 2006 - Elsevier
Hormonal therapy and chemotherapy play a major role in the management of advanced or
recurrent endometrial cancer. Progesterone therapy obtains overall response rates ranging …

Lapatinib and potential prognostic value of EGFR mutations in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer

KK Leslie, MW Sill, HA Lankes, EG Fischer… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: A phase II trial was performed to evaluate the efficacy and safety of the tyrosine
kinase inhibitor of epidermal growth factor receptor (EGFR) and HER2, lapatinib, and to …

Endometrial cancer

KK Leslie, KW Thiel, MJ Goodheart… - Obstetrics and …, 2012 - obgyn.theclinics.com
• In 2009, the International Federation of Gynecology and Obstetrics revised the staging
system for carcinomas of the endometrium; major changes include grouping stages IA and …

A phase II evaluation of gefitinib in the treatment of persistent or recurrent endometrial cancer: a Gynecologic Oncology Group study

KK Leslie, MW Sill, E Fischer, KM Darcy, RS Mannel… - Gynecologic …, 2013 - Elsevier
BACKGROUND: A phase II trial was performed to evaluate the efficacy and safety of gefitinib
in patients with persistent/recurrent endometrial cancer. METHODS: Women with …

Systemic therapy in metastatic or recurrent endometrial cancer

D Pectasides, E Pectasides, T Economopoulos - Cancer treatment reviews, 2007 - Elsevier
Endometrial cancer is one of the most common gynecologic malignancies. In patients with
advanced or recurrent endometrial cancer survival is greatly diminished. Hormonal therapy …

Endometrial cancer: molecular and therapeutic aspects

P Tsikouras, S Bouchlariotou, N Vrachnis… - European Journal of …, 2013 - Elsevier
Endometrial cancer (EC) is the most commonly diagnosed gynecologic malignancy.
Although early-stage EC is effectively treated surgically, commonly without adjuvant therapy …

Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma

S Cai, Y Zhang, K Han, Y Ding - Archives of Gynecology and Obstetrics, 2017 - Springer
Objective The article is to study the expressions of COX-2, VEGF-C, and EGFR in
endometrial carcinoma as well as its clinical significances. Materials and methods Clinical …

Endometrial cancer: what is new in adjuvant and molecularly targeted therapy?

F Zagouri, G Bozas, E Kafantari… - Obstetrics and …, 2010 - Wiley Online Library
Endometrial cancer is the most common gynaecological cancer in western countries.
Radiotherapy remains the mainstay of postoperative management, but accumulating data …

Promising novel therapies for the treatment of endometrial cancer

PA Gehrig, VL Bae-Jump - Gynecologic oncology, 2010 - Elsevier
OBJECTIVES: To discuss the novel agents which are being developed for the treatment of
advanced and recurrent endometrial carcinoma and to review other molecular targets that …