Tissue morphogenesis occurs in a complex physicochemical microenvironment with limited
experimental accessibility. This often prevents a clear identification of the processes that …

Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …

Tissue morphogenesis results from a tight interplay between gene expression, biochemical
signaling and mechanics. Although sequencing methods allow the generation of cell …

The optimal functioning of many organs relies on the curved architecture of their epithelial
tissues. However, the mechanoresponse of epithelia to changes in curvature remains …

Living systems adopt a diversity of curved and highly dynamic shapes. These diverse
morphologies appear on many length scales, from cells to tissues and organismal scales …

The heterogeneity of bones is elegantly adapted to the local strain environment, which is
critical for maintaining mechanical functions. Such an adaptation enables the strong …

As a model of the intestinal epithelium, intestinal stem cells (ISCs) are grown and
differentiated as monolayers on materials where stochastic organization of the crypt and villi …

Surface morphological patterns are widely observed in natural systems, which are closely
correlated to vital biological functions and inspire surface morphology designs in soft matter …

Cell fate determination, a vital process in early development and adulthood, has been the
focal point of intensive investigation over the past decades. Its importance lies in its critical …

Cells exert forces on each other and their environment, shaping the tissue. The resulting
mechanical stresses can be determined experimentally or estimated computationally using …