Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells
and facilitate cancer development and progression. However, recent evidence suggests the …

Malignant cells support tumor proliferation and progression by adopting to metabolic
changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of …

Cancer cells exhibit an altered metabolism which is characterized by a preference for
aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic …

The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

Pancreatic cancer patients have poor survival rates and are frequently treated using
gemcitabine (Gem). However, initial tumor sensitivity often gives way to rapid development …

This review examines recent applications of stable copper, zinc and sulfur isotopes to
medical cases and notably cancer. The distribution of the natural stable isotopes of a …

Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a
promising anticancer therapeutic target. Our previous work suggests that coumarin …

Background Clear-cell renal cell carcinoma (ccRCC) exhibits suppressed mitochondrial
function and preferential use of glycolysis even in normoxia, promoting proliferation and …

Purpose: To assess whether anaerobic metabolism, proliferation activity and stem cell
content are linked with radioresistance in bladder cancer. Materials and methods: Tissue …

One may wonder how a paper discussing medical applications of metal isotopes got lost in a
review journal dedicated to mineralogy and geochemistry. The justifications are multiple …