Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular
hemoglobin (Hb) has been found to trigger specific pathophysiologies that are associated …

Chemically modified or genetically engineered haemoglobins (Hbs) developed as oxygen
therapeutics (often termed'blood substitutes') are designed to correct oxygen deficit due to …

Skeletal muscle-tissue engineering can be applied to produce cell-based meat for human
consumption, but growth parameters need to be optimized for efficient production and …

Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

Aneurismal subarachnoid haemorrhage (SAH) is a devastating disease that is associated
with significant morbidity and mortality. The mortality is approximately 50%, with 30% of …

Persistent safety concerns have stalled the development of viable hemoglobin (Hb)-based
oxygen carriers (HBOCs). HBOCs have several advantages over human blood, including …

In the past few decades, extensive studies have been performed and have shown the
causative role of ironmediated lipid peroxidation (LPO) in human diseases and in the …

Pentacoordinate respiratory hemoproteins such as hemoglobin and myoglobin have
evolved to supply cells with oxygen. However, these respiratory heme proteins are also …

Detoxification and clearance of extracellular hemoglobin (Hb) have been attributed to its
removal by the CD163 scavenger receptor pathway. However, even low-level hydrogen …

Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe
oxidative damage as a consequence of heme redox cycling between ferric and ferryl states …