3D cell culture systems modeling tumor growth determinants in cancer target discovery
CR Thoma, M Zimmermann, I Agarkova… - Advanced drug delivery …, 2014 - Elsevier
Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and
the microenvironment are key determinants of the multistep process of tumor development …
the microenvironment are key determinants of the multistep process of tumor development …
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
BA Schulman, J Wade Harper - Nature reviews Molecular cell biology, 2009 - nature.com
Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …
multienzyme cascades is a central mechanism to modulate protein functions. This process is …
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation
During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …
disrupting the genes involved in antigen processing and presentation or up-regulating …
Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras
The genetic dependencies of human cancers widely vary. Here, we catalog this
heterogeneity and use it to identify functional gene interactions and genotype-dependent …
heterogeneity and use it to identify functional gene interactions and genotype-dependent …
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which
mainstream treatments have not changed for decades. To identify additional therapeutic …
mainstream treatments have not changed for decades. To identify additional therapeutic …
Chromatin-modifying enzymes as modulators of reprogramming
Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming
involves global epigenetic remodelling. Whereas several proteins are known to regulate …
involves global epigenetic remodelling. Whereas several proteins are known to regulate …
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21. 1 losses in malignant pleural mesothelioma
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation, but
other highly recurrent mutations have not been described. To identify additional driver …
other highly recurrent mutations have not been described. To identify additional driver …
[HTML][HTML] Principles of cancer therapy: oncogene and non-oncogene addiction
Cancer is a complex collection of distinct genetic diseases united by common hallmarks.
Here, we expand upon the classic hallmarks to include the stress phenotypes of …
Here, we expand upon the classic hallmarks to include the stress phenotypes of …
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
KL Meerbrey, G Hu, JD Kessler… - Proceedings of the …, 2011 - National Acad Sciences
The discovery of RNAi has revolutionized loss-of-function genetic studies in mammalian
systems. However, significant challenges still remain to fully exploit RNAi for mammalian …
systems. However, significant challenges still remain to fully exploit RNAi for mammalian …
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …
genes based on the observation that similar mutational phenotypes arise from functionally …