Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

Epigenetics refers to a variety of processes that have heritable effects on gene expression
programs without changes in DNA sequence. Key players in epigenetic control are chemical …

Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic
reticulum (ER) is a central feature of secretory cells and is observed in many tissues in …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants
originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta …

Endoplasmic reticulum (ER) stress has been linked to many diseases, including cancer. A
large body of work has focused on the activation of the ER stress response in cancer cells to …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

MBD5 and MBD6 are two members of the methyl‐CpG‐binding domain (MBD) family of
proteins that are poorly characterized. Studies performed thus far have failed to show …

Previous studies have suggested that endoplasmic reticulum stress (ERS) is one of the
mechanisms responsible for the pathogenesis of diabetic nephropathy (DN). Histone …

Maintaining proteostasis is important for animal development. How proteostasis influences
spermatogenesis that generates male gametes, spermatozoa, is not clear. We show that …