In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across
diverse areas of biology and medicine. The recognition of mitochondria as a major …

In human beings, there is a∼ 16,569 bp circular mitochondrial DNA (mtDNA) encoding 22
tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos …

RNA import into mammalian mitochondria is considered essential for replication,
transcription, and translation of the mitochondrial genome but the pathway (s) and factors …

Mitochondria are not only important for cellular bioenergetics but also lie at the heart of
critical metabolic pathways. They can rapidly adjust themselves in response to changing …

The cellular processes are controlled by a narrow range of mRNA and proteins levels,
where small RNAs (sRNAs) known as miRNAs play a critical role. The spatial and temporal …

During evolution, most of the bacterial genes from the ancestral endosymbiotic α-
proteobacteria at the origin of mitochondria have been either lost or transferred to the …

All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can
be traced down to a single endosymbiotic event between two probably prokaryotic …

In many eukaryotes, tRNA import from the cytosol into mitochondria is essential for
mitochondrial biogenesis and, consequently, for cell viability. Recent work has begun to …

Mitochondrial translation is important for the synthesis of proteins involved in oxidative
phosphorylation, which yields the bulk of the ATP made in cells. During evolution most …

The voltage-dependent anion-selective channel (VDAC) is the most abundant protein in the
mitochondrial outer membrane and the major transport pathway for a large variety of …