Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Distinct classes of motor neurons and ventral interneurons are generated by the graded
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …

The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and
the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a …

Vertebrate gastrulation involves the specification and coordinated movement of large
populations of cells that give rise to the ectodermal, mesodermal and endodermal germ …

The prosomeric model attributes morphological meaning to gene expression patterns and
other data in the forebrain. It divides this territory into the same transverse segments …

During vertebrate development, the specification of distinct cell types is thought to be
controlled by inductive signals acting at different concentration thresholds. The degree of …

The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when
administered to gastrulation-stage amniote embryos. Cyclopamine-induced malformations …

Neurogenin1 (Ngn1), Neurogenin2 (Ngn2), and Mash1 encode bHLH transcription factors
with neuronal determination functions. In the telencephalon, the Ngns and Mash1 are …